The melanoma genomics managing your risk study: A protocol for a randomized controlled trial evaluating the impact of personal genomic risk information on skin cancer prevention behaviors

AK Smit; AJ Newson; RL Morton; M Kimlin; L Keogh; MH Law; J Kirk; S Dobbinson; PA Kanetsky; G Fenton; M Allen; P Butow; K Dunlop; L Trevena; S Lo; J Savard; H Dawkins; S Wordsworth; M Jenkins; GJ Mann; AE Cust

Journal article

The melanoma genomics managing your risk study: A protocol for a randomized controlled trial evaluating the impact of personal genomic risk information on skin cancer prevention behaviors

AK Smit, AJ Newson, RL Morton, M Kimlin, L Keogh, MH Law, J Kirk, S Dobbinson, PA Kanetsky, G Fenton, M Allen, P Butow, K Dunlop, L Trevena, S Lo, J Savard, H Dawkins, S Wordsworth, M Jenkins, GJ Mann Show all

Contemporary Clinical Trials | ELSEVIER SCIENCE INC | Published : 2018

DOI: 10.1016/j.cct.2018.05.014

Abstract

Background: Reducing ultraviolet radiation (UV) exposure and improving early detection may reduce melanoma incidence, mortality and health system costs. This study aims to evaluate the efficacy and cost-effectiveness of providing information on personal genomic risk of melanoma in reducing UV exposure at 12 months, according to low and high traditional risk. Methods: In this randomized controlled trial, participants (target sample = 892) will be recruited from the general population, and randomized (1:1 ratio, intervention versus control). Intervention arm participants provide a saliva sample, receive personalized melanoma genomic risk information, a genetic counselor phone call, and an educ..

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University of Melbourne Researchers

Louise Keogh Author

Mark Jenkins Author

Related Projects (1)

IMPROVING SKIN CANCER PREVENTION : MOTIVATING PREVENTIVE BEHAVIOURS USING KNOWLEDGE OF PERSONALISED GENOMIC RISK OF MELANOMA

The aim of our study is to evaluate whether we can improve the Australian public’s skin cancer prevention behaviours, particularly reducing ..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This study is funded by the National Health and Medical Research Council of Australia (NHMRC; project grant 1129822). AEC received Career Development Fellowships from the NHMRC (1147843) and Cancer Institute NSW (15/CDF/1-14). AKS received a Research Training Program (RTP) Stipend Scholarship and a Merit Top Up Scholarship from the University of Sydney, and a Top Up Scholar Award from the Sydney Catalyst Translational Cancer Research Centre. RLM received funding from an NHMRC Sidney Sax Fellowship (1054216). MGK is supported through a Cancer Council Queensland Professorial Chair. We thank Professor Bruce Armstrong for initial feedback on the study design. The study has been endorsed by the Australian and New Zealand Melanoma Trials Group, ANZMTG 03.17.